Biochemical documentation of allelic variation of the I-E antigens of the d, k, p, r, and u haplotypes

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Abstract
The extent of allelic variation of the Eα and E β polypeptide chains of the I-E antigens from the H-2> d ,H-2 k , H-2 p , H-2 r , and H-2 u haplotypes is described. Eα and E β chains were individually labeled with arginine or lysine and compared by tryptic peptide analysis. The results indicate minimum variability among the Eα polypeptides encoded by the d, k, p, and r haplotypes. However, the E α u chain differed significantly from the other allelic Eα gene products. On the other hand, the E β alleles demonstrated substantial variability with the E β d being notably less similar to the other alleles than they are to each other. These findings are consistent with a number of observations regarding the serology and functions of the I-E antigens.

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