Coma Produced by Topical Application of Isopropanol
- 1 April 1969
- journal article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 43 (4) , 622-623
- https://doi.org/10.1542/peds.43.4.622
Abstract
The topical use of isopropyl alcohol to reduce fever in children is a common procedure in pediatric practice. Deep coma has been reported in two children, presumably from inhalation of the alcohol during sponging procedures in poorly ventilated areas.1,2 Absorption through the skin has not been reported to be a significant portal of entry.3 The toxic effects of ingested isopropanol in humans are reported to be similar to those of ethanol, but they occur at lower blood concentrations.4 The lethal dose for adults of ingested 70% isopropyl alcohol has been estimated to be 240 ml.5 The following case is reported as an example of coma in an infant following injudicious topical application of isopropanol for the relief of fever.Keywords
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