Effect of histamine methylation inhibitors on entry of14C-histamine into brain

1 April 1978

journal article
research article
Published by Springer Nature in Inflammation Research

Vol. 8 (3) , 203-205
https://doi.org/10.1007/bf01966604

Abstract

Pretreatment of mice, rats and guinea pigs with inhibitors of histamine methylation, followed by sytemic injection of¹⁴C-histamine, results in a significant increase in brain¹⁴C-histamine relative to controls. It is suggested that the histamine methylating enzyme participates in the bloodbrain barrier to histamine.

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