Reduction of Folate by Ti3+
- 1 November 1972
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 50 (11) , 1183-1190
- https://doi.org/10.1139/o72-161
Abstract
Both folate and 7,8-dihydrofolate can be reduced by TiCl3, but the reduction of dihydrofolate requires a temperature above 30°. The reaction of folate with Ti3+ proceeds with rapid formation of a complex between the metal and the pterin coenzyme, with a stoichiometry of 2 Ti: 1 folate. Kinetic experiments have shown that the reduction of folate takes place as a slower reaction, after the formation of the intermediate complex. A possible structure of the intermediate and mechanism for the reduction reactions is presented.Keywords
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