A Genetic Variant of Factor IX with Decreased Capacity for Ca2+ Binding
- 1 August 1979
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 42 (4) , 623-635
- https://doi.org/10.1111/j.1365-2141.1979.tb01175.x
Abstract
Summary. A genetic variant of factor IX is described that behaves identically to PIVKA IX (the precursor factor IX molecule induced by the absence of vitamin K or presence of vitamin K antagonists, acarboxy factor IX). It shows an increased electrophoretic mobility in the presence of Ca2+, a low affinity for adsorption to A1(OH)3 and a very low specific coagulant activity. This variant of factor IX has been demonstrated in the plasma of a patient with severe haemophilia B and in the plasmas of a number of possible carriers from the probands’ pedigree.This publication has 17 references indexed in Scilit:
- Immunological Heterogeneity of Haemophilia B: a Multicentre Study of 98 KindredsBritish Journal of Haematology, 1978
- Studies on human factor IX by immunoelectrophoretic and immunodiffusion methodsThrombosis Research, 1978
- Inhibitor-neutralisation assay and electro-immuno assay of human factor IX (Christmas factor)Clinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B.Journal of Clinical Investigation, 1977
- An Immunological Investigation of Hemophilia B with a Tentative Classification of the Disease into Five Variants1Vox Sanguinis, 1977
- Electroimmunoassay of factor IX in hemophilia BThrombosis Research, 1975
- Binding of Ca2+ to normal and dicoumarol-induced prothrombinBiochemical and Biophysical Research Communications, 1973
- The Levels of Factors II, VII, IX and X by Antibody Neutralization Techniques in the Plasma of Patients Receiving Phenindione TherapyBritish Journal of Haematology, 1971
- Genetic variants of hemophilia B: detection by means of a specific PTC inhibitorJournal of Clinical Investigation, 1968
- Plasma Prothrombin during Treatment with DicumarolScandinavian Journal of Clinical and Laboratory Investigation, 1968