Structure characterization of reaction products from phenylhydrazonopropanedinitrile and thiols
- 1 January 1985
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 50 (2) , 375-382
- https://doi.org/10.1135/cccc19850375
Abstract
Phenylhydrazonopropanedinitriles react with thiols (benzyl mercaptan, cysteine, 2-mercaptoethanol, mercaptoacetic acid, glutathione, and alcohol dehydrogenase) to give addition products in which thiolate anion is attached to electrophilic carbon atom of cyano group. The reaction ability and way of reaction of phenylhydrazonopropanedinitriles are discussed in the context of mechanism of biological activity of these compounds, particularly that of their uncoupling effect on oxidative phosphorylation.Keywords
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