Complement Activation during Subsequent Stages of Canine Endotoxin Shock

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Abstract
Changes in total hemolytic complement (C) and levels of C3, C4 and C6 were studied during subsequent stages of lethal [Escherichia coli] endotoxin shock in dogs. Substantial decreases of all parameters were observed. C4 and C6 decreases showed a very similar pattern, indicating activation of C by the classical pathway in addition to the activation of the alternative pathway known to occur in this pathological condition. The role of the C system in the pathophysiology of endotoxin shock are emphasized. C activation has prognostic value during endotoxemia.