Cyclosporin A Inhibits Calcineurin/Nuclear Factor of Activated T-Cells Signaling and Induces Apoptosis in Retinoblastoma Cells

1 March 2005

journal article
research article
Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science

Vol. 46 (3) , 782-790
https://doi.org/10.1167/iovs.04-1022

Abstract

Purpose. Although the clinical efficacy of cyclosporin A (CSA) in retinoblastoma (RB) has been attributed to multidrug resistance reversal activity, the authors hypothesized that CSA is also directly toxic to RB cells through inhibition of calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling.

Keywords

APOPTOSIS
CYCLOSPORIN
RETINOBLASTOMA
FACTOR OF ACTIVATED
MULTIDRUG RESISTANCE
INHIBITS CALCINEURIN/NUCLEAR
CALCINEURIN/NUCLEAR FACTOR
EFFICACY

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