Heterogeneity of histamine N-methyltransferase.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 29 (8) , 2379-2382
- https://doi.org/10.1248/cpb.29.2379
Abstract
The distribution of histamine N-methyltransferase (HMT) activity was studied in various tissues [brain, stomach, lung, kidney, intestine, heart, liver] of the guinea pig and rat. The properties of HMT in rat kidney differ from those of HMT in the brain and kidney of the guinea pig and the brain of the rat. Quinacrine, a potent HMT inhibitor, inhibited the activity of HMT by 50% at concentrations of about 10-5 M in rat kidney and about 10-7 M in other tissues.This publication has 1 reference indexed in Scilit:
- RAT AND MOUSE BRAIN HISTAMINE N‐METHYLTRANSFERASE: MODULATION BY METHYLATED INDOLEAMINES1Journal of Neurochemistry, 1978