In vitro activity of mezlocillin and azlocillin compared with that of four other penicillins and two aminoglycosides

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Abstract
The vitro activity of mezlocillin and azlocillin was compared with that of carbenicillin, ticarcillin, piperacillin, ampicillin, amikacin and gentamicin. Microdilution susceptibility tests were performed with 484 bacterial isolates collected from 6 separate medical centers. Against Pseudomonas aeruginosa, the activity of mezlocillin resembled that of carbenicillin and azlocillin resembled the more active drug, piperacillin. Against other gram-negative bacilli, the activity of mezlocillin resembled that of piperacillin, and azlocillin had a unique spectrum of activity. All 6 penicillins were active against streptococci and penicillin-susceptible Staphylococcus aureus but were ineffective against penicillin-resistant S. aureus. Amikacin and gentamicin inhibited a slightly larger proportion of strains than did the broad spectrum penicillins included in this study.