HEMOLYTIC UREMIC SYNDROME WITH HYPOCOMPLEMENTEMIA, SERUM C3NEF, AND GLOMERULAR DEPOSITS OF C3

  • 1 January 1977
    • journal article
    • research article
    • Vol. 101  (7) , 357-361
Abstract
A 4 yr old boy had hemolytic uremic syndrome (HUS) associated with depression of serum [complement component] C3 level, a .beta.-hemolytic streptococcal throat infection and an elevated level of antistreptolysin O titer. In addition to the characteristic histologic changes associated with this syndrome, substantial infiltration of polymorphonuclear leukocytes and nodular deposits of C3 globulin were seen in the glomeruli of the 1st biopsy specimen. Two months after clinical remission, he had a recurrence of hemolytic anemia, thrombocytopenia and acute renal failure. Serum C3 concentration had decreased and serum C3NeF was detected in the serum. The typical changes associated with HUS were still present on EM. Bilateral nephrectomy and renal transplantation were done because of the development of uncontrollable severe hypertension and increasing azotemia. The patient had 3 manifestations of HUS, but because of differences such as hypocomplementemia, serum C3NeF, a recurrence and persistent glomerular deposits of C3 globulin, he appeared to have had a different form of the syndrome.

This publication has 0 references indexed in Scilit: