Neutralization of "Long-Acting Thyroid Stimulator" of Graves' Disease by Antisera to Bovine Pituitary Thyrotropin.
- 1 December 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 108 (3) , 780-784
- https://doi.org/10.3181/00379727-108-27065
Abstract
A globulin concentrate from antiserum to bovine pituitary thyrotropin completely neutralized the effect on the thyroid of "long-acting thyroid stimulator" (LMS) in the serum of patients with Graves'' disease. Both early and late responses in the McKenzie assay were abolished. A globulin concentrate from normal rabbit serum had no neutralizing effect. About 10 times as much antibody was required to neutralize LATS as the approximately equivalent potency of human pituitary thyrotropin.Keywords
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