GAS-CHROMATOGRAPHIC DETERMINATION OF THE SOLUBILITY COEFFICIENT FOR VOLATILE ANESTHETICS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 28  (3) , 104-106
Abstract
To determine the solubility coefficient of volatile anesthetics in Schindler''s liquid culture, modified by Karzel, a gas-chromatographic analysis with direct-injection-method was used. A well defined volume with a known concentration of the anesthetic was added to a vessel with known volume. After equilibration, the concentration of the inhalational anesthetics was determined in the liquid at various temperatures. The solubility coefficient and the temperature coefficient were calculated from these data. The following solubility coefficients were obtained at 24.degree. C (and at 37.degree. C): for halothane 1.07 (0.77), for enflurane 1.14 (0.70), for methoxyflurane 4.92 (3.23) and for isoflurane 1.13 (0.82). In Schindler''s liquid culture modified by Karzel the values of at 24.degree. (37.degree.) were: for halothane 1.33 (0.92), for enflurane 1.32 (0.87), for methoxyflurane 6.61 (4.48) and for isoflurane 1.19 (0.98). The temperature coefficient for the temperature range were in water (in Schindler''s liquid culture) for halothane -2.31 .cntdot. 10-2 K-1 (-3.15 .cntdot. 10-2 K-1), for methoxyflurane -13.0 .cntdot. 10-2 K-1 (-16.48 .cntdot. 10-2 K-1), for enflurane -3.38 .cntdot. 10-2 K-1 (-3.46 .cntdot. 10-2 K-1) and for isoflurane -2.38 .cntdot. 10-2 K-1 (-1.62 .cntdot. 10-2 K-1).