Effect of Glucagon on Heart

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To the Editor: Parmley et al., in their report on "Cardiovascular Effects of Glucagon in Man" in the July 4 issue of the Journal, described quite nicely the inotropic and chronotropic effects of glucagon. However, on the basis of previous studies with epinephrine and glucagon in vitro,1 these authors suggested that glucagon did not act through the increased formation of cyclic 3′,5′-AMP as hypothesized for epinephrine. This conclusion was based primarily on the observation that beta-adrenergic blocking agents prevented the effects of epinephrine but did not alter the effects of glucagon. The editorial, "Control of Cardiac-Muscle Contraction," in the same . . .

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