The response of human cerebral edema to glucosteroid administration

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Abstract
A morphological description of the effect of dexamethasone, a potent glucosteroid, upon cerebral edema occurring in 15 patients was presented. The ultrastructural characteristics of edema were reviewed and changes in this edema after dexamethasone administration described. Dexamethasone definitely reduces the amount of brain swelling, particularly in terms of astrocyte cytoplasm and the extracellular accumulation of fluid in the white matter. The edematous brains are returned toward a normal configuration by the administration of the drug. A hypothesis for a mechanism of action of the steroid was presented.

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