In vitro Inactivation of Cell-Free Marek's Disease Herpesvirus by Immune Peripheral Blood Lymphocytes

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Abstract
The effect of peripheral blood lymphocytes (PBL) on cell-free Marek''s disease virus (MDV) was studied in vitro in PBL from intact or embryonal bursectomized (Bx) chicks infected with the apathogenic SB-1 isolate of MDV. The PBL were harvested, purifiied and were mixed, 200 or 2000 to 1, with cell-free GA-5 of MDV. Virus survival was assayed after incubation for 1 h at 36.degree. C by the standard assay for cell-free MDV. PBL from intact but not Bx chickens inactivation no longer occurred, suggesting that it resulted from cooperation between macrophages and B[bursa derived]-cells.

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