Does Acute Poststreptococcal Glomerulonephritis Lead to Chronic Renal Disease?

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Abstract
That acute rheumatic fever secondary to streptococcal infection frequently results in chronic valvular heart disease, sometimes after a quiescent period of many years, inevitably suggests that acute poststreptococcal glomerulonephritis similarly may lead to chronic glomerulonephritis. However, this association, or lack of it, between acute and chronic glomerular inflammatory disease remains one of the most contested issues in contemporary nephrology.Because chronic glomerulonephritis is the leading cause of chronic renal failure the issue of its cause is of compelling interest. In recent years a series of advances have elucidated the pathogenetic mechanisms that lead to glomerular inflammation. At least two types . . .

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