Responsiveness of Cerebral Osmoreceptors in the Anesthetized Dog

Publisher Website
Google Scholar
Abstract
Experiments were carried out to determine if, in the anesthetized dog undergoing a water diuresis, selective elevation of cerebral osmolality induced an antidiuresis. Bilateral intracarotid infusion of hypertonic sodium chloride in an amount previously shown to increase jugular plasma osmolality by 3% was associated with a significant decline in CH2O. The same volume of hypertonic sodium chloride infused intravenously did not alter CH2O significantly. These experiments do not support the view that anesthesia blocks the response of cerebral osmoreceptors.