Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR Imaging

1 January 1996

journal article
Published by Springer Nature in Pharmaceutical Research

Vol. 13 (3) , 376-380
https://doi.org/10.1023/a:1016084224084

Abstract

Purpose. The purpose of this study was to characterise the water mobility in the gel layer of hydrating HPMC tablets. Water mobility in the gel layer of different HPMCs was studied. Methods. NMR...

Keywords

HYDROPHILIC MATRIX
SELF-DIFFUSION COEFFICIENT
WATER MOBILITY
T2 RELAXATION
NMR-IMAGING
NMR-MICROSCOPY
HYDROXYPROPYLMETHYLCELLULOSE (HPMC)

This publication has 2 references indexed in Scilit:

NMR microscopy of hydrating hydrophilic matrix pharmaceutical tablets
Magnetic Resonance Imaging, 1994
Hydrophilic matrix sustained release systems based on polysaccharide carriers.
1991