CA-ACCUMULATING CAPACITY OF MYOCARDIAL AND SMOOTH-MUSCLE MEMBRANES OF RATS WITH SPONTANEOUS GENETIC-HYPERTENSION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 20  (2) , 94-+
Abstract
The features of Ca binding and accumulation by the membrane fractions of the myocardium, aorta and uterus of rats with spontaneous genetic hypertension (SHR) were studied by the method of radioisotope exchange. A decrease in the Ca-accumulating capacity of the reticulum and increase in that of the mitochondria of the SHR myocardium as compared to the Ca-accumulating property of the myocardial fractions of rats with normal arterial pressure were demonstrated. The changes in intracellular accumulation of Ca in the SHR aorta are linked with the membranes of the sarcolemma in which the ATP-dependent and ATP-independent binding of Ca was found to be reduced. The membrane Ca-accumulating capacity was changed in cells of smooth muscles not exposed to the direct long-term effect of increased arterial pressure: the Ca-accumulating capacity of the mitochondria of the SHR uterus is 1.3-1.6 times less than that in animals with normal arterial pressure.

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