Relations of plasma 25-hydroxyvitamin D levels in mothers, cord blood and newborn infants, and postnatal changes in plasma 25-hydroxy-vitamin D levels.

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Abstract
The plasma levels of 25-hydroxyvitamin D (25-OH-D) were determined in 27 healthy mothers, their infants, in the cord blood at the time of delivery and in another 95 children of different ages. The plasma 25-OH-D levels in the infants, cord blood and mothers at the time of delivery were 11.4 .+-. 8.6 ng/ml (mean .+-. SD, n = 27), 12.8 .+-. 8.2 ng/ml (mean .+-. SD, n = 25) and 16.3 .+-. 8.1 ng/ml (mean .+-. SD, n = 27), respectively. These values are significantly lower (P < 0.01) than the value of 21.6 .+-. 10.1 ng/ml (mean .+-. SD, n = 17) in normal children (1-15 yr of age). Significant correlations were found between the plasma 25-OH-D levels of the infants and the mothers, and between those of the mothers and cord bloods, with correlation coefficients of r = 0.62, (P < 0.01, n = 27) and r = 0.78 (P < 0.01, n = 25), respectively. The plasma 25-OH-D concentration was normally maintained at a low level for 1-2 mo. after birth and then rose. No significant correlation was found between the plasma 25-OH-D and plasma Ca levels. 25-OH-D is apparently transferred from the mother to the infant through the placenta, but that the blood 25-OH-D level is low for a few months after birth, possibly due to a low rate of 25-hydroxylation of vitamin D during this period.

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