LONG SPACING COLLAGEN IN DERMAL DISORDERS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 27  (4) , 265-271
Abstract
EM studies of biopsy material from the vulva of 6 patients with lichen sclerosus et atrophicus and 2 patients with condyloma latum, and from the skin of the back and shoulder of 1 patient with scleromyxedema and the forearm of 1 patient with macular amyloidosis revealed the presence of long spacing collagen (LSC) intermingled with an increased amount of ground substance and extracellular microfibrils. This presence of LSC in condyloma latum may be the first reported. The LSC displayed an axial periodicity of 1000-2000 .ANG.. The appearance of LSC is not specific of any disorder and the formation of LSC is associated with the presence of increased amounts of glycosaminoglycan-rich ground substance and the abundance of microfilaments in the extracellular space.

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