Chemical and biological reactions of diacetato[2-(dimethylaminomethyl)-phenyl]gold(III), [Au(O2CMe)2(dmamp)]
- 1 January 1996
- journal article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 1,p. 69-74
- https://doi.org/10.1039/dt9960000069
Abstract
The gold(III) complex [Au(O2CMe)2(dmamp)][dmamp = 2-(dimethylaminomethyl)phenyl] is hydrolysed in wholly or partially aqueous solution. One acetate ligand, presumed to be that trans to the Au–C bond, exchanged with a water molecule rapidly on the NMR time-scale. At high concentrations of water a further hydrolysis step was also discernible, which involved the second acetate group while, in aged solutions, small amounts of a third species, possibly the second isomer of [Au(O2CMe)(dmamp)(H2O)]+, was formed. The reaction of aqueous or dimethyl sulfoxide solutions of the gold(III) complex with various biological ligands was followed by NMR spectroscopy and a range of reactivities was found: caffeine and adenosine showed no reaction, L-cysteine, glutathione and adenine reacted quantitatively and guanosine and inosine showed partial reaction. In in vitro biological tests for antibacterial activity, [Au(O2CMe)2(dmamp)] exhibited a potentially useful selectivity.Keywords
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