Fatty acid oxidation in relation to cholesterol biosynthesis in rats
- 1 November 1966
- Vol. 1 (6) , 415-421
- https://doi.org/10.1007/bf02532545
Abstract
Groups of male and female rats were fed diets containing (calorie basis) 2% corn oil (low‐fat, LF), 42% corn oil (CO) or 2% corn oil plus 40% beef tallow (BT) for 2 weeks. Then rats of each sex and diet group were given an intraperitoneal injection of14C‐acetate,‐ stearate‐ oleate or linoleate. Acetate incorporation into cholesterol and rate of oxidation of each fatty acid were determined. Specific activity of cholesterol was higher in females than males, higher with 40% lipid in the diet than with 2% corn oil and higher for CO than BT. Linoleate was oxidized more rapidly than oleate which exceeded stearate. An index of dietary lipid oxidation was computed based on fatty acid oxidation rate, per cent of each fatty acid in the diet and per cent of lipid calories in the diet. Serum cholesterol‐14C was found to be proportional to dietary lipid oxidation index.This publication has 34 references indexed in Scilit:
- Labeling of liver and serum cholesterol esters after the injection of cholesterol-4-C14 and cholesterol-4-C14 estersArchives of Biochemistry and Biophysics, 1966
- Immediate fate of albumin-bound [1-14C]stearic acid following its intraportal injection into carbohydrate refed ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
- Sterol and bile acid excretion in man and the effects of dietary fat.Journal of Clinical Investigation, 1965
- Relationship between utilization of fat and synthesis of cholesterol and total lipid in young female ratsJournal of Oil & Fat Industries, 1965
- The Metabolism of Fatty Acids in the Rat VIII. Lauric Acid and Myristic AcidActa Physiologica Scandinavica, 1965
- Cholesterol synthesis by the gastrointestinal tract: localization and mechanisms of control.Journal of Clinical Investigation, 1965
- Chain-shortening of stearic acid in the intact ratBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
- Substrate specificity of the fatty acid oxidase in the heartArchives of Biochemistry and Biophysics, 1964
- METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS*Journal of Clinical Investigation, 1963
- Oxidation and activation of unsaturated fatty acidsArchives of Biochemistry and Biophysics, 1959