STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection withListeria monocytogenes
Open Access
- 1 January 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (1) , 416-418
- https://doi.org/10.1128/iai.70.1.416-418.2002
Abstract
We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killedListeria monocytogenes,STK-deficient mice exhibit increased susceptibility to infection withListeria.Keywords
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