Cardiovascular and metabolic effects of natriuretic peptides
- 18 November 2005
- journal article
- review article
- Published by Wiley in Fundamental & Clinical Pharmacology
- Vol. 20 (1) , 41-49
- https://doi.org/10.1111/j.1472-8206.2005.00379.x
Abstract
Natriuretic peptides (NP) are essential in mammals to regulate blood volume and pressure. The functional roles of NP are not limited to natriuresis and diuresis. Several peripheral and central actions of the peptides have been characterized. Studies on transgenic mice have revealed their key function in the regulation of cardiomyocyte growth. Plasma NP levels increase in patients with cardiovascular disorders and heart failure. They represent useful clinical markers for clinicians to diagnose heart diseases. The recent discovery of their potent lipolytic action in adipose tissue is a breakthrough in cardiovascular medicine. This new function of NP in the regulation of lipid metabolism offers interesting questions in the field of obesity, diabetes and cardiovascular diseases. This review will briefly describe the effects of NP on the cardiovascular system and lipid metabolism.Keywords
This publication has 119 references indexed in Scilit:
- Safety and feasibility of using serial infusions of nesiritide for heart failure in an outpatient setting (from the FUSION I trial)The American Journal of Cardiology, 2004
- Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese womenInternational Journal of Obesity, 2002
- Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase IThe Journal of Experimental Medicine, 1999
- Comparison of secretion pattern between A-type and B-type natriuretic peptides in patients with old myocardial infarctionJournal of the American College of Cardiology, 1995
- Natriuretic Peptides Inhibit DNA Synthesis in Cardiac FibroblastsHypertension, 1995
- Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes.Hypertension, 1990
- Effect of reducing atrial pressure on atrial natriuretic factor and vasoactive hormones in congestive heart failure secondary to ischemic and nonischemic dilated cardiomyopathyThe American Journal of Cardiology, 1989
- Cellular mechanism of release of atrial natriuretic factorBiochemical and Biophysical Research Communications, 1984
- Rat atrial natriuretic factor: Complete amino acid sequence and disulfide linkage essential for biological activityBiochemical and Biophysical Research Communications, 1984
- A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in ratsLife Sciences, 1981