Randomization: Perils and Problems

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Abstract
To the Editor: As an advocate of randomized clinical trial as the only reliable method so far designed to distinguish between therapies that are not overwhelmingly different, I should like to comment on the article, "Allocation of Subjects in Experiments" (N Engl J Med 291:1278–1285, 1974).In the first place, I object to the assumption that randomization implies a greater interest in future patients than in the patients entering the study in question. An equal case can be made for randomization to result in a better chance that a patient will receive the proper therapy, in view of the fact . . .

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