In depolarized and glucose‐deprived neurons, Na+ influx reverses plasmalemmal K+‐dependent and K+‐independent Na+/Ca2+ exchangers and contributes to NMDA excitotoxicity
Open Access
- 11 December 2002
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 83 (6) , 1321-1328
- https://doi.org/10.1046/j.1471-4159.2002.01227.x
Abstract
Cerebellar granule cells (CGCs) express K+‐dependent (NCKX) and K+‐independent (NCX) plasmalemmal Na+/Ca2+ exchangers which, under plasma membrane‐depolarizing conditions and high cytosolic [Na+], ma...Keywords
This publication has 46 references indexed in Scilit:
- Instrumental role of Na+ in NMDA excitotoxicity in glucose‐deprived and depolarized cerebellar granule cellsJournal of Neurochemistry, 2002
- Sodium/Calcium Exchange: Its Physiological ImplicationsPhysiological Reviews, 1999
- Extracellular Potassium in a Neocortical Core Area After Transient Focal IschemiaStroke, 1997
- A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ HomeostasisJournal of Neurochemistry, 1996
- The Quantity of Calcium that Appears to Induce Neuronal DeathJournal of Neurochemistry, 1994
- Inhibition of the red blood cell calcium pump by eosin and other fluorescein analoguesAmerican Journal of Physiology-Cell Physiology, 1993
- Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.Stroke, 1989
- Extrusion of calcium from rod outer segments is driven by both sodium and potassium gradientsNature, 1989
- Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 1984
- The extracellular potassium concentration in brain cortex following ischemia in hypo‐ and hyperglycemic ratsActa Physiologica Scandinavica, 1978