Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver

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Abstract
Putative preneoplastic foci of rat liver, so far believed to be deficient in monooxygenases, are shown to contain a cytochrome P450 isoenzyme inducible by phenobarbital. The iso-enzyme is also present and appears catalytically active in liver tumors obtained after promotion with phenobarbital and α-hexachlorocyclohexane.