A CASE OF HEREDITARY COMBINED DEFICIENCY OF COMPLEMENT COMPONENTS C6 AND C7 IN MAN
- 1 March 1989
- journal article
- research article
- Vol. 75 (3) , 396-401
Abstract
Immunological investigation of a patient presenting with candidiasis and toxoplasmosis revealed a combined deficiency of C6 and C7. Deficiency of C6 was total, but small amounts (less than 1 .mu.g/ml) of apparently normal C7 were present in the serum. All family members (three sibs and both parents) were heterozygous for the combined deficiency. This is only the second reported case of combined homozygous deficiency of the closely linked and immunochemically similar proteins C6 and C7, and only the third kindred in which this defect has been demonstrated.This publication has 26 references indexed in Scilit:
- DEFICIENCY OF THE 6TH COMPONENT OF COMPLEMENT AND SUSCEPTIBILITY TO NEISSERIA-MENINGITIDIS INFECTIONS - STUDIES IN 10 FAMILIES AND 5 ISOLATED CASES1987
- FAMILY STUDY ON THE POLYMORPHISMS OF THE 6TH AND 7TH COMPONENTS (C6 AND C7) OF HUMAN-COMPLEMENT - LINKAGE AND HAPLOTYPE ANALYSES1986
- Inherited deficiencies of complement and complement-related proteinsClinical Immunology and Immunopathology, 1986
- Arthritis and antinuclear antibodies (ANA) with inherited deficiency of the sixth component of complement (C6).Annals of the Rheumatic Diseases, 1986
- Inherited Complement Component AbnormalitiesAnnual Review of Medicine, 1986
- Immunological detection of the sixth complement component (C6) following flat bed polyacrylamide gel isoelectric focusing and electrophoretic transfer to nitrocellulose filtersAnnals of Human Genetics, 1983
- Characterization of human complement components C6 and C7Molecular Immunology, 1982
- Toxoplasmosis Dangerous in Complement DeficiencyNew England Journal of Medicine, 1977
- Escherichia coli Antibody: A Screening Test for ImmunodeficiencyBMJ, 1974
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970