A metabotropic glutamate receptor variant functions as a taste receptor
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- 1 February 2000
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 3 (2) , 113-119
- https://doi.org/10.1038/72053
Abstract
Sensory transduction for many taste stimuli such as sugars, some bitter compounds and amino acids is thought to be mediated via G protein-coupled receptors (GPCRs), although no such receptors that respond to taste stimuli are yet identified. Monosodium L-glutamate (l-MSG), a natural component of many foods, is an important gustatory stimulus believed to signal dietary protein. We describe a GPCR cloned from rat taste buds and functionally expressed in CHO cells. The receptor couples negatively to a cAMP cascade and shows an unusual concentration–response relationship. The similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.Keywords
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