PREGNANCIES FOLLOWING CHRONIC INTERMITTENT (PULSATILE) ADMINISTRATION OF Gn-RH BY MEANS OF A PORTABLE PUMP (“ZYKLOMAT”) - A NEW APPROACH TO THE TREATMENT OF INFERTILITY IN HYPOTHALAMIC AMENORRHEA

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Abstract
In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device (“Zyklomat”) was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 5o μl of a Gn-RH containing solution once eyery 9o minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.