Testicular Function in Klinefelter’s Syndrome

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Abstract
Testicular venous effluent was obtained by selective catheterization from 2 subjects with chromatin-positive Klinefelter''s syndrome. In both of these subjects the testosterone concentration was reduced, whereas the estradiol concentration was normal or slightly incresed in 1 and reduced to a much lesser extent than the testosterone level in the other. The testosterone/estradiol ratios in both subjects were in the range of 180, whereas in the normal subjects the mean testosterone/estradiol ratio in the spermatic venous effluent was 582.