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Abstract
A system for clarifying different syndromes of familial hyperlipoproteinemia is presented based on a simple paper electro-phoretic technique which separates 4 groups of plasma lippproteins. Different abnormal lipoprotein patterns recurring in kindreds are compared with respect to fat and carbohydrate induction of hyperlipemia, plasma lipoprotein lipase activity, xanthomas, glucose tolerance, and other clinical features. From such comparisons there emerge at least 5 distinct syndromes that may be expressions of different genotypes, but this is not proved. These are designated as Type L the rare fat-induced hyperchylomicronemia; Type II, hyper-beta lipoproteinemia (familial hypercholesterolemia); Type III, elevated beta and pre-beta lipoprotein, for which there is evidence of further sub-types; Type IV, increased pre-beta lipoprotein; and Type V, having features of both Type I and IV. The system is proposed as a base for both further genotyping and easier clinical management of diseases associated with elevated plasma lipids.

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