Pantothenic Acid in the Nutrition of the Rat

Publisher Website
Google Scholar
Abstract
Rats fed a synthetic ration deficient in pantothenic acid became gray in 4–6 weeks. Levels of calcium pantothenate above 40 μg. per day prevented or cured this condition. The rate of growth paralleled the level of pantothenic acid intake up to 80 μg. per day. Studies on the urinary excretion of this vitamin indicated that the daily requirement for the growing rat is approximately 100 μg. of calcium pantothenate per day. Rats fed a heated grain ration showed graying which was likewise prevented and cured with synthetic calcium pantothenate. Copper deficiency caused a graying which did not respond to pantothenic acid but was rapidly cured by administration of copper. Feeding hydroquinone failed to produce graying in rats receiving synthetic or milk rations. p-Aminobenzoic acid was entirely ineffective against the graying produced in rats by feeding a synthetic ration under our experimental condition.

This publication has 30 references indexed in Scilit: