PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WITH CHRONIC HEMOLYTIC ANEMIA
- 1 June 1951
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Internal Medicine
- Vol. 87 (6) , 868-878
- https://doi.org/10.1001/archinte.1951.03810060097010
Abstract
PAROXYSMAL nocturnal hemoglobinuria with chronic hemolytic anemia was first described as a clinical entity by Chauffard and Troisier in 1908.1Subsequent reports by Marchiafava,2later amplified by Micheli,3resulted in the eponym Marchiafava-Micheli syndrome. A total of 73 reported cases, including 16 postmortem studies, was collected by Marks in 1949.4Studies on the pathogenesis of the disease have been pursued in recent years by Ham,5Dacie6and others.7The fundamental abnormality appears to reside within or on the surface of the red cell, thus rendering it susceptible to external influences not ordinarily reactive on the normal erythrocyte. In the following report a case of paroxysmal nocturnal hemoglobinuria with chronic hemolytic anemia is presented. The outstanding feature was the long history of regularly recurring nausea and vomiting associated with abdominal pain. The diagnosis was made only a few weeks prior to death. Postmortem observations are included.This publication has 0 references indexed in Scilit: