Targeted Retroviral Infection of Tumor Cells by Receptor Cooperation
Open Access
- 15 February 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (4) , 2753-2756
- https://doi.org/10.1128/jvi.77.4.2753-2756.2003
Abstract
Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein.Keywords
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