Studies on the metabolism of animals on a carbohydrate-free diet

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Abstract
Rats and mice are more resistant to the effects of insulin when fed on carbohydrate-free diets of cheese and caseinogen than with carbohydrate-rich diets. In kittens, neither a diet consisting entirely of protein nor one containing a large amount of fat increases resistance to insulin. In fact these animals are somewhat less responsive to insulin on a carbohydrate-rich diet than on a carbohydrate-free diet. Resistance of rodents to insulin is not due to the amount of stored glycogen or to any specific food substance but is dependent upon variations in the acid-base equilibrium. A non-carbohydrate diet lowers the alkali reserve of rats and mice but not of kittens.