TRISOMY 10P - PREVIOUS OBSERVATION REEXAMINED AFTER R-BANDING

  • 1 January 1976
    • journal article
    • research article
    • Vol. 19  (1) , 61-64
Abstract
A previously reported male infant having died at 4 mo, was considered trisomic Cp, his mother being carrier of balanced translocation t(Cp-;Bq+). Reexamination of the chromosome complement after R-banding showed the translocation to be t(4;10)(q35;p11). The propositus was therefore trisomic 10p. The essential clinical features were a small birth weight and a short birth length, hypotonia, psychomotor retardation, dolichocephalia, a high and bulky forehead, narrow lips, large lowset ears with a posterior rotation, a small chin, bone and joint anomalies and dextrocardia. This observation is discussed and compared to 8 other cases previously reported.

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