Binding of (+)PHNO and other D2-dopamine agonists to D1-dopamine receptors labelled by [3H]SCH 23390
- 1 March 1987
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 69 (1-2) , 147-151
- https://doi.org/10.1007/bf01244105
Abstract
The affinity of (+)PHNO for the D1-dopamine receptor subtype in striatal tissue was determined in a radioligand binding assay using the D1-selective compound, [3H]SCH 23390. The IC50 for (+)PHNO was 22ΜM, a value considerably higher than obtained for reference agents (lisuride, apomorphine, pergolide, [−]EOE and bromocriptine). The low potency of (+)PHNO at the D1-receptor subtype contrasts with the compound's high potency at the D2-receptor subtype, as reported previously. (+)PHNO can, therefore, be classified as a very selective D2-receptor agonist.This publication has 12 references indexed in Scilit:
- (+)-4-PROPYL-9-HYDROXYNAPHTHOXAZINE (PHNO), A NEW DOPAMINOMIMETIC, IN TREATMENT OF PARKINSONISMThe Lancet, 1985
- A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatumLife Sciences, 1985
- Binding of [3H]SCH23390 in Rat Brain: Regional Distribution and Effects of Assay Conditions and GTP Suggest Interactions at a D1-Like Dopamine ReceptorJournal of Neurochemistry, 1985
- The therapeutic potential of centrally acting dopamine agonistsTrends in Pharmacological Sciences, 1984
- Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonistsJournal of Medicinal Chemistry, 1984
- Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatumLife Sciences, 1984
- Potent dopamine agonist activity of a novel ergoline, 6-Ethyl-9-oxaergoline (EOE)Life Sciences, 1982
- Dopaminergic Mechanisms in the Teleost RetinaJournal of Neurochemistry, 1981
- The role of D-1 and D-2 receptorsNature, 1980
- Multiple receptors for dopamineNature, 1979