hERG potassium channels and cardiac arrhythmia
Top Cited Papers
- 22 March 2006
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 440 (7083) , 463-469
- https://doi.org/10.1038/nature04710
Abstract
HERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs. This side effect is a common reason for drug failure in preclinical safety trials. Insights gained from the crystal structures of other potassium channels have helped our understanding of the block of hERG channels and the mechanisms of gating.Keywords
This publication has 87 references indexed in Scilit:
- Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + ChannelScience, 2005
- Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methodsFEBS Letters, 2005
- Differential Inhibition of Inducible T Cell Cytokine Secretion by Potent Iron ChelatorsSLAS Discovery, 2005
- Expression of multiple KCNE genes in human heart may enable variable modulation ofJournal of Molecular and Cellular Cardiology, 2005
- Pentamidine-Induced Long QT Syndrome and Block of hERG TraffickingThe Journal of Pharmacology and Experimental Therapeutics, 2005
- Critical assessment of a proposed model of ShakerFEBS Letters, 2004
- X-ray structure of a voltage-dependent K+ channelNature, 2003
- The open pore conformation of potassium channelsNature, 2002
- Crystal structure and mechanism of a calcium-gated potassium channelNature, 2002
- The Structure of the Potassium Channel: Molecular Basis of K + Conduction and SelectivityScience, 1998