Fucose-Binding Lotus tetragonolobus Lectin Binds to Human Polymorphonuclear Leukocytes and Induces a Chemotactic Response

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Abstract
Summary: Fucose-binding L. tetragonolobus lectin binds to the surface of human polymorphonuclear leukocytes (PMN) and induces a chemotactic response. Both surface binding and chemotaxis are inhibited by free fucose but not by fructose, mannose, or galactose. The lectin-binding sites on PMN are unrelated to the A, B, or O blood group antigen. Utilization of this lectin should be a useful tool in isolating PMN membrane components and in analyzing the mechanism of neutrophil chemotaxis.