Effect of Hemodilution, Hemoconcentration and β-Adrenergic Stimulation on the Blood Flow and Membrane Potential Value of the Liver

Publisher Website
Google Scholar
Abstract
The hyperpolarization produced by isoproterenol is concurrent with an increased blood flow through the isolated dog liver. This observation suggested a relationship between membrane potential (MP) and blood flow which has been investigated.An increase in blood flow can be obtained by hemodilution without modifying the MP values. On the other hand, hyperpolarization has been produced without modification of the blood flow by the administration of adrenaline in combination with an α-blocking agent. Identical results have also been observed with isoproterenol when the flow rate was previously increased by hemodilution. Therefore, the hyperpolarization produced by stimulation of the β-adrenergic receptors is not a simple consequence of an improved blood supply to the liver. A 38% reduction of the blood flow by hemoconcentration has a very limited influence on the MP during hypothermic perfusion. This result contrasts with those of defective perfusions when a similar flow rate was concomitant with a significantly lower MP value. In that case a primary cellular injury or an uneven perfusion through the organ could be implicated in addition to the overall reduction in blood flow.

This publication has 0 references indexed in Scilit: