Food and Fasting Absorption of a Single Dose of a Sustained Release Theophylline Sprinkle Formulation in Children

Publisher Website
Google Scholar
Abstract
The bioavailability and absorption pattern of theophylline from a single dose of a slow release theophylline sprinkle product (Somophyllin®) were investigated in 10 asthmatic children both in Fasting conditions and after a standerdized breakfast. Theophylline given intravenously was used as a reference. The fasting absorption of. Somophyllin was rather fast with peak serum theophylline levels 3–5 h (mean 3.7 h) after dosing. Food produced a small bin statistically significant reduction in the rate of absorption of theopylline. so that the mean time to peak serum theophyllne level was 5.6 h (range 4–8 h) after food. In no case was there any important difference between the absorption) profiles on the test days, and the bioavailability was complete after both fasted and fed intake of the product (92.5% and 105%, respectively). It is suggested hat to obtain the optimum absorption profile children should take Somophyllin with food rather than between meals.