Glycosphingolipid Biosynthesis May Not Be Necessary for Vertebrate Brain Developmenta
- 1 June 1998
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 845 (1 SPHINGOL) , 215-218
- https://doi.org/10.1111/j.1749-6632.1998.tb09673.x
Abstract
Glycosphingolipids (GSLs) in general and gangliosides in particular have long been considered essential for CNS growth and development. Recent studies with intact developing systems in fish and mice challenge this general notion. These studies suggest that glycosphingolipid biosynthesis and expression is neither essential nor necessary for neural growth and differentiation in the developing vertebrate brain. Rather than having a major role in neural cell growth and morphogenesis, the GSLs may have a role in modulating such membrane properties as signaling, electrical conduction, maintenance, and stability.Keywords
This publication has 11 references indexed in Scilit:
- Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.Proceedings of the National Academy of Sciences, 1996
- Inhibitors of Glycosphingolipid Biosynthesis.Trends in Glycoscience and Glycotechnology, 1995
- Phylogenetic conservation of ganglioside GD3 expression during early vertebrate ontogenyComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1994
- Immunohistochemical localization of minor gangliosides in the rat central nervous systemGlycobiology, 1994
- A ceramide analogue (PDMP) inhibits glycolipid synthesis in fish embryosExperimental Cell Research, 1992
- Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver.Proceedings of the National Academy of Sciences, 1988
- Effect of purkinje cell loss on cerebellar gangliosides in nervous mutant miceJournal of Neuroscience Research, 1987
- Cellular Distribution of Gangliosides in the Developing Mouse Cerebellum: Analysis Using the Staggerer MutantJournal of Neurochemistry, 1984
- Cellular Localization of Gangliosides in the Developing Mouse Cerebellum: Analysis Using the Weaver MutantJournal of Neurochemistry, 1983
- Differential Cellular Enrichment of Gangliosides in the Mouse Cerebellum: Analysis Using Neurological MutantsJournal of Neurochemistry, 1982