Estrogens and Transport of Ova in the Rat.
- 1 August 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 116 (4) , 1032-1034
- https://doi.org/10.3181/00379727-116-29441
Abstract
Summary Inhibition of implantation in the rat may be partially accomplished by a single dose of 10 or 15 μg of estrone per rat administered on day 1 of pregnancy; a single dose of 20 μg per rat appears to cause complete inhibition. Doses of 20 μg per rat or higher cause a premature passage of tubal ova into the uterus with later expulsion from the uterus. This loss of ova and consequent lack of implantation cannot be counteracted by daily preimplantation doses of 5 mg progesterone, or 1 mg of the two synthetic potent progestins: (1)1,2a-methylene-6-chloro-6-dehydro-17 α-hydroxyprogesterone-17-acetate; (2) 3α7α-diacetoxy-6a-methylpregn-4-en-20-one.Keywords
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