STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT

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Abstract
A specific disease entity was established in white mice by the nasal instillation of lung and exudate suspensions from each of 14 adult albino rats affected with endemic pneumonia. The induced disease was characterized by pneumonia (96%), otitis media (94%) and rhinitis (30%). It progressed slowly after an incubation period of 7[long dash]14 days and was attended by a variable mortality which reached ;33% in 22 weeks. Maintenance of the disease was regularly accomplished by direct transmission from mouse to mouse but only by the nasal route and only from the 3 foci of involvement. It was also transmissible by direct contact but required a prolonged period of exposure. The relation of the disease to infectious catarrh, which it closely resembles, is discussed.

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