The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible
- 1 August 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 235 (1-2) , 211-214
- https://doi.org/10.1016/0014-5793(88)81264-x
Abstract
The hydrolysis of ATP that accompanies the polymerization of actin occurs on the F-actin subsequent to the addition of the G-ATP-actin subunit to the elongating filament. We now show that this ATP hydrolysis is essentially irreversible. Thus, a large decrease in free energy occurs at the cleavage step, F-ATP-actin → F-ADP-Pi-actin.Keywords
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