Topical methoxsalen followed immediately by long-wave UV irradiation. A preliminary report on the treatment of psoriasis

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Abstract
In the treatment of psoriasis with topically applied methoxsalen, the patient is exposed to long-wave UV (UV-A) energy 2 h after the application of methoxsalen. Using the guinea pig as an experimental model, UV-A irradiation given immediately after the topical application of methoxsalen resulted in the notable suppression of tritiated thymidine incorporation into epidermal basal cells. The rate of suppression of epidermal DNA synthesis by PUVA (methoxsalen plus UV-A light) may not correlate with the interval between methoxsalen application and UV-A irradiation. This modified method of PUVA therapy (immediate irradiation) was successfully used in the treatment of psoriasis.