SigE Is a Chaperone for the Salmonella enterica Serovar Typhimurium Invasion Protein SigD

Abstract
SigD is translocated into eucaryotic cells by a type III secretion system. In this work, evidence that the putative chaperone SigE directly interacts with SigD is presented. A bacterial two-hybrid system demonstrated that SigE can interact with itself and SigD. In addition, SigD was specifically copurified with SigE-His 6 on a nickel column.